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 Technology Profile

Title:

Polymeric Liposomal Formulation for Keratitis

Value Proposition:
  • Enhances corneal bioavailability and prolongs residence time of antimicrobial drugs via polymeric liposomal delivery.
  • Provides sustained and controlled drug release, maintaining therapeutic levels for longer duration.
  • Reduces dose and dosing frequency, improving patient compliance.
  • Minimizes systemic exposure and toxicity, particularly for drugs like amphotericin B.
  • Offers a non-invasive, corneal-targeted eye drop formulation for effective keratitis treatment with reduced time to cure.
Summary Application:
  • A polymeric liposomal eye drop formulation for treating keratitis effectively.
  • Composed of lipids, cholesterol, CSA polymer, and antimicrobial agents.
  • Enhances corneal drug penetration and ocular retention.
  • Ensures controlled release, reducing both dose and dosing frequency.
  • Improves therapeutic efficacy while reducing systemic toxicity.
Advantages:
  • Enhanced treatment effect while reducing dose and dosing frequency.
  • Prolonged ocular residence to improve keratitis treatment outcomes.
  • Sustained therapeutic effect from controlled drug release.
  • Easy administration and improved patient compliance.
Commercialization Status: Licensed awaiting commercialisation
Tech. Readiness Level:
CSIR-Central Drug Research Institute
CSIR-Central Drug Research Institute[CSIR-CDRI]
:  director[at]cdri[dot]res[dot]in
:91-522-2772450
:https://www.cdri.res.in
Industrial Applications: Formulations [Drugs and Pharmaceuticals]
Patent Application(s): IN202111015517