New Invention Profile
| Publication No: | CN118525019 [China] | Application No: | CN202380015831 |
| Title: | Process for the preparation of ledipasvir | ||
| Publication Date: | 20-08-2024 | File Date: | 24-11-2023 |
| Inventor(s): | Gangarajula, Sudhakar; Chennam, Ramu; Kumaraguru, Thenkrishnan; Baburao Rode, Haridas; Maddi Reddy, Sridhar; Chada Reddy, Raji; Ghosh, Subhash | ||
| IPC Classification: | C07D 047108, C07C 027122, C07D 040304, C07D 040314 | ||
| Abstract: | The present disclosure relates to a process for preparing ledipasvir (I) or a pharmaceutically acceptable salt thereof. The present disclosure also provides novel intermediates (IV to XI) for the synthesis of ledipasvir. The main strategy of the present invention is the late stage functionalization of key intermediates of ledipasvir (I), such as difluorination and cyclopropanation. (I) |
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Industrial Applications
Chemistry, Chemical Processes Polymers [Chemistry, Chemical Processes]
Synhtesis Procesess [Drugs and Pharmaceuticals]