New Invention Profile
| Publication No: | WO2023148783 [PCT] | Application No: | PCT/IN2023/050123 |
| Title: | Process for the preparation of nafamostat, camostat and their derivatives | ||
| Publication Date: | 10-08-2023 | File Date: | 07-02-2023 |
| Inventor(s): | Ahmed Riyaz; Kumar Gulshan; Mahajan Sheena; Verma Praveen Kumar; Cham Pankaj Singh; Kumar Amit; Ahmed Qazi Naveed; Reddy Dumbala Srinivasa; Shankar Ravi; Singh Parvinder Pal | ||
| IPC Classification: | A61K31/245, A61P1/02, C07C277/08 | ||
| Abstract: | The invention provides a novel, economical and practical route for the synthesis of an ester from acid and alcoholic functionalities using Trihalotriazine as coupling agent. Specifically, the invention provides a novel, economical and practical route for the preparation of Nafamostat and Camostat. Synthesis of p-guanidinobenzoic acid (A1) was also achieved from thiourea and p-aminobenzoic acid by using trihalotriazine as coupling reagent. | ||
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