Technology Profile
| Title: | Production of Mitochondrial Superoxide Dismutase (mSOD) Enzyme |
| Value Proposition: | The enzyme was also unusually stable towards various denaturation agents such as urea and guanidine hydrochloride. Owing to its antioxidant potential, the enzyme finds applications in the food, pharmaceutical, and cosmetic industries. |
| Summary Application: | Technology for the production of a mitochondrial superoxide dismutase (mSOD) having a very high level of thermal-stability. The recombinant enzyme exhibited a specific activity of 1015.54 ± 14.6 units/mg of protein at its temperature optima of 4 °C and is highly resistant towards thermal inactivation [half-life of thermal inactivation (t1/2) at 70 °C = 176.33 ± 15.7 min]. The enzyme was also unusually stable towards various denaturation agents such as urea and guanidine hydrochloride. Owing to its antioxidant potential, the enzyme finds applications in the food, pharmaceutical, and cosmetic industries. |
| Advantages: | Highly thermostable nature, coupled with unusually high stability of mSOD towards various denaturating agents, makes it suitable for industrial applications. |
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