New Invention Profile
| Publication No: | CN118043310 [China] | Application No: | CN202280064064 |
| Title: | Pyrazolamide-based compounds and their use for breast cancer | ||
| Publication Date: | 14-05-2024 | File Date: | 16-11-2022 |
| Inventor(s): | Sulochana, Priya; Sasidhar Balappa, Somappa; Kozhiparambil Gopalan, Raghu; Sreerenjini, Lakshmi; Kizhakkan Thiruthi, Ashitha | ||
| IPC Classification: | C07D 023114, A61K 0031415, A61K 00314155, A61P 003500, C07D 040912 | ||
| Abstract: | The disclosure provides novel pyrazole amide derivatives represented by the formula (formula I), in the formula (formula I), when R=-CH2 -, then R1 can be benzene, 4-methylbenzene, 4-methoxybenzene, 4-chlorobenzene, 4-fluorobenzene, 2-chlorobenzene, 3,4-dichlorobenzene, 3. 5-trifluoromethylbenzene, and when R = -SO2-, then R1 may be one of benzene, 4-methoxybenzene, 4-chlorobenzene, 4-bromobenzene, 4-trifluoromethylbenzene, 3-trifluoromethylbenzene, 2-bromobenzene, 2-chlorothiophene, 2,3-dichlorothiophene substituents. The present disclosure also relates to compounds of formula (I) for use as anti-cancer agents in tri-negative breast cancer (TNBC) cells. The present disclosure determines the effectiveness of pyrazolamide derivatives of formula I (I-8) against TNBC cells by interacting with a variety of cellular pathways to induce cell death in a variety of mechanisms. |
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