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Publication No: WO2023089632 [World Intellectual Property Organization (WIPO)] Application No: WO2022IN51006
Title: PYRAZOLE AMIDE BASED COMPOUNDS AND USES AGAINST BREAST CANCER THEREOF
Publication Date: 25-05-2023 File Date: 16-11-2022
Inventor(s): Sulochana, Priya; Sasidhar Balappa, Somappa; Kozhiparambil Gopalan, Raghu; Sreerenjini, Lakshmi; Kizhakkan Thiruthi, Ashitha
IPC Classification: A61P 003500, A61K 0031415, C07D 023114
Abstract:
The present disclosure provides new derivatives of pyrazole amide represented by the formula (Formula I) in which when R= -CH 2-, then R1 may be one among benzene, 4-methyl benzene, 4-methoxy benzene, 4-chloro benzene, 4-fluoro benzene, 2-chloro benzene, 3,4-dichloro benzene, 3,5-trifluoromethylbenzene, and when R= -SO2-, then R1 may be one among benzene, 4-methoxy benzene, 4-chloro benzene, 4-bromo benzene, 4-trifluoromethyl benzene, 3-trifluoromethyl benzene, 2-bromo benzene, 2-chlorothiophen, 2,3-dichlorothiophen substituents. The disclosure also relates to compounds of formula (I) for its use as an anticancer agent in triple negative breast cancer (TNBC) cells. The disclosure established the effectiveness of the pyrazole amide derivative of formula I (I-8), against TNBC cells by inducing cell death by various mechanisms through interaction with diverse cellular pathways.

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