New Invention Profile
| Publication No: | IN202411007892 [India] | Application No: | IN202411007892 |
| Title: | Quinoline-triazole compound as potential anti-filarial agents and a process for preparation thereof | ||
| Publication Date: | 15-08-2025 | File Date: | 05-02-2024 |
| Inventor(s): | Koneni Venkata Sashidhara; Mrigank Srivastava; Prabhat Ranjan Mishra; Sarita Katiyar; Shikha Mishra; Abhishek Kumar; Avijit Kumar Bakshi; Ruchi Jha | ||
| IPC Classification: | A61K31/498, A61K31/4709, A61P33/02, A61K45/06, A61K9/48 | ||
| Abstract: | The present invention relates to a quinoline-triazole compound of Formula I and pharmaceutically acceptable salts thereof. The present invention further relates to the process of synthesis and biological activity of quinoline-triazole compounds of Formula I as anti-filarial agents and pharmaceutically acceptable salts thereof. These compounds exhibited potent microfilaricidal and adulticidal activity against human filarial pathogen Brugia malayi when tested under in vitro and in vivo conditions using rodent models of filariasis viz. Meriones unguiculatus and Mastomys coucha which are permissive to Brugian infection. |
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Industrial Applications
Chemistry, Chemical Processes Polymers [Chemistry, Chemical Processes]
Formulations [Drugs and Pharmaceuticals]
NCE [Drugs and Pharmaceuticals]
Synhtesis Procesess [Drugs and Pharmaceuticals]