New Invention Profile
| Publication No: | AU2022287326 [Australia] | Application No: | AU2022287326 |
| Title: | siRNA DELIVERY VECTOR | ||
| Publication Date: | 30-11-2023 | File Date: | 03-06-2022 |
| Inventor(s): | Kotamraju, Srigiridhar; Bathula, Surendar Reddy; Shaikh, Altab; Neeli, Praveen Kumar; Sravya, Panangipalli; Banerjee, Rajkumar; Thennati, Rajamannar; Gajalakshmi, Singuru | ||
| IPC Classification: | A61K 004754, A61K 003137, C07F 000954, C12N 0015113 | ||
| Abstract: | There is provided a complex of a 6,7-dihydroxy coumarin phosphonium amphiphile together with a negatively charged agent. The complex self-assembles into a nanoparticle or non-viral vector for facilitating delivery of the negatively charged agent. The negatively charged agent may be a therapeutic agent or a diagnostic agent. Thus, the present invention provides a method of delivery of such negatively charged agents to a target cell, and in particular facilitates delivery of a therapeutic or diagnostic agent across the plasma membrane, as well as a method of treatment or diagnosis via delivery of the therapeutic or diagnostic agent. The 6,7-dihydroxy coumarin phosphonium amphiphile can be Mito-Esc and the negatively charged agent can be a nucleic acid such as siRNA. Additionally, the 6,7-dihydroxy coumarin phosphonium amphiphile is believed to be effective in the treatment of cancer. |
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Industrial Applications
Synhtesis Procesess [Drugs and Pharmaceuticals]