New Invention Profile
| Publication No: | EP4346902 [European Patent Office (EPO)] | Application No: | EP22741839 |
| Title: | siRNA delivery vector | ||
| Publication Date: | 10-04-2024 | File Date: | 03-06-2022 |
| Inventor(s): | Kotamraju Srigiridhar; Bathula Surendar Reddy; Shaikh Altab; Neeli Praveen Kumar; Sravya Panangipalli; Banerjee Rajkumar; Thennati Rajamannar; Gajalakshmi Singuru | ||
| IPC Classification: | A61K47/54, A61K31/37, A61P35/00, C07F9/54, C12N15/113 | ||
| Abstract: | There is provided a complex of a 6,7-dihydroxy coumarin phosphonium amphiphile together with a negatively charged agent. The complex self-assembles into a nanoparticle or non-viral vector for facilitating delivery of the negatively charged agent. The negatively charged agent may be a therapeutic agent or a diagnostic agent. Thus, the present invention provides a method of delivery of such negatively charged agents to a target cell, and in particular facilitates delivery of a therapeutic or diagnostic agent across the plasma membrane, as well as a method of treatment or diagnosis via delivery of the therapeutic or diagnostic agent. The 6,7-dihydroxy coumarin phosphonium amphiphile can be Mito-Esc and the negatively charged agent can be a nucleic acid such as siRNA. Additionally, the 6,7-dihydroxy coumarin phosphonium amphiphile is believed to be effective in the treatment of cancer. | ||
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Industrial Applications
Composites [Materials]
Diagnostics [Medical Devices and Diagnostics]
Inorganic materials [Chemistry, Chemical Processes]
Nanomaterials [Materials]