New Invention Profile
| Publication No: | US20240269106 [USA] | Application No: | US18565911 |
| Title: | Small molecule modulator targeting a rare histone modification regulating adipogenesis and pharmaceutical formulation thereof | ||
| Publication Date: | 15-08-2024 | File Date: | 30-11-2023 |
| Inventor(s): | Kundu, Tapas Kumar; Bhattacharya, Aditya; Chatterjee, Sourav; Koneni, Venkata Sashidhara; Singh, Suriya Pratap; Mishra, Prabhat Ranjan; Nazir, Aamir; Guha, Rajdeep | ||
| IPC Classification: | A61K 0031352, A61K 000900, A61K 003638, A61K 004710, A61K 004714 | ||
| Abstract: | The present invention relates to substituted benzophenones of structural Formula I employed as small molecule inhibitor for controlling obesity. The present invention further relates to screening of small molecule inhibitors against p300 which selectively targets histone butyrylation thereby specifically inhibiting adipogenesis further aiding to prevention of weight gain. The present invention reveals that histone butyrylation increases during adipogenesis. Hence, inhibition of histone butyrylation by a small molecule inhibitor would be a promising therapeutic strategy to control obesity. Significantly, besides inhibiting adipogenesis in cellular model, it also prevents weight gain in high fat diet based mouse model system, indicating the possible use of the scaffold for obesity control. |
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:91-522-2772450
:https://www.cdri.res.in
Industrial Applications
Chemistry, Chemical Processes Polymers [Chemistry, Chemical Processes]
Synhtesis Procesess [Drugs and Pharmaceuticals]