New Invention Profile
| Publication No: | IN202311034981 [India] | Application No: | IN202311034981 |
| Title: | Small molecules for adoptive t-cell therapy (act) through activation of the MTOR signalling pathway, process for prepartion thereof | ||
| Publication Date: | 22-11-2024 | File Date: | 18-05-2023 |
| Inventor(s): | Arindam Talukdar; Shilpak Chatterjee; Sunny Goon; Dipika Sarkar; Puspendu Ghosh; Uddipta Ghosh Dastidar; Trisha Ghosh | ||
| IPC Classification: | A61P 35/00, A61K 35/17, A61K 8/44, C07D 471/14, A61K 31/436 | ||
| Abstract: | The present invention relates to the preparation of 8-phenyl-purine-6-amino compounds with general structure I in free form or in acceptable salt form to identify small molecule activator of mTOR, which can be used to augment the effector function (IFN? production) of T cells and hence heightened their antitumor response. More particularly, the invention relates to small molecules where R1, R2 and R3 are as defined in the description, capable of IFN? production via mTOR activation pathway to elicit durable antitumor repose in the host. The invention describes strategies to generate T cells with high effector function, yet in a relatively short period of time so that a robust and durable anti-tumor response can be achieved in the host. |
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Industrial Applications
Chemistry, Chemical Processes Polymers [Chemistry, Chemical Processes]
NCE [Drugs and Pharmaceuticals]