| Publication No: | IN202411059522 [India] | Application No: | IN202411059522 |
| Title: | Strontium niobate bio-ceramics & composites for accelerated skeletal regeneration and a process for the preparation thereof | ||
| Publication Date: | 13-02-2026 | File Date: | 06-08-2024 |
| Inventor(s): | Datta Pradyot; Sarkar Tuhin; Kundu Biswanath; Balla Vamsi Krishna | ||
| IPC Classification: | A61L27/46, A61L27/12, A61P19/00, A61L27/32, C01B25/32 | ||
| Abstract: | Strontium Niobate Bio-Ceramics & Composites for Accelerated Skeletal Regeneration and a Process for the Preparation Thereof The present invention relates to a non- calcium phosphate bio-ceramic and composite for accelerated skeletal regeneration and process to manufacture thereof which comprises a new range of non-calcium phosphate bioceramic and composite of strontium carbonate and niobium oxide for biomedical applications, faster skeletal regeneration and process to manufacture thereof. It is a range of new compositions of hydroxyapatite (HAp) and strontium niobate (Sr2Nb2O7) based bioceramic and composites using hydroxyapatite (HAp), strontium carbonate (SrCO3) and niobium oxide (Nb2O5) for biomedical application, especially for faster bone skeletal regeneration by a process which is simple, easy to operate, low in preparation cost and easy to popularize. Addition of strontium niobate (SNB) as part of new composition provides piezo/ferroelectric properties and enhanced fracture toughness, 5% porosity, hydrophilic surface (potential of unfavorable environment for bacteria attachment and biofilm formation), bone mineralization, did not show cytotoxicity effect on MC3T3 cells in vitro. HSN3 and HSN5 exhibited best cytoskeleton which indicates that beneficial effect of cell proliferation and cell-to-cell communication. HSN1, HSN2, HSN3 and HSN5 composites revealed significant increase in cell proliferation during entire cell culture period for 3, 5 and 7 days with respect to pure hydroxyapatite (HAp). |
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