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Publication No: IN202411059522 [India] Application No: IN202411059522
Title: Strontium niobate bio-ceramics & composites for accelerated skeletal regeneration and a process for the preparation thereof
Publication Date: 13-02-2026 File Date: 06-08-2024
Inventor(s): Datta Pradyot; Sarkar Tuhin; Kundu Biswanath; Balla Vamsi Krishna
IPC Classification: A61L27/46, A61L27/12, A61P19/00, A61L27/32, C01B25/32
Abstract:
Strontium Niobate Bio-Ceramics & Composites for Accelerated Skeletal Regeneration and a Process for the Preparation Thereof The present invention relates to a non- calcium phosphate bio-ceramic and composite for accelerated skeletal regeneration and process to manufacture thereof which comprises a new range of non-calcium  phosphate bioceramic and composite of strontium carbonate and niobium oxide for biomedical applications, faster skeletal regeneration and process to manufacture  thereof. It is a range of new compositions of hydroxyapatite (HAp) and strontium niobate (Sr2Nb2O7) based bioceramic and composites using hydroxyapatite (HAp),  strontium carbonate (SrCO3) and niobium oxide (Nb2O5) for biomedical application, especially for faster bone skeletal regeneration by a process which is simple, easy  to operate, low in preparation cost and easy to popularize. Addition of strontium niobate (SNB) as part of new composition provides piezo/ferroelectric properties and  enhanced fracture toughness, 5% porosity, hydrophilic surface (potential of unfavorable environment for bacteria attachment and biofilm formation), bone  mineralization, did not show cytotoxicity effect on MC3T3 cells in vitro. HSN3 and HSN5 exhibited best cytoskeleton which indicates that beneficial effect of cell  proliferation and cell-to-cell communication. HSN1, HSN2, HSN3 and HSN5 composites revealed significant increase in cell proliferation during entire cell culture  period for 3, 5 and 7 days with respect to pure hydroxyapatite (HAp).
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