New Invention Profile
| Publication No: | EP4554676 [European Patent Office (EPO)] | Application No: | EP23839191 |
| Title: | SUBSTITUTED 3-METHYLBENZO[D]THIAZOL-3-IUM COMPOUNDS AND USE THEREOF | ||
| Publication Date: | 21-05-2025 | File Date: | 12-07-2023 |
| Inventor(s): | Goel Atul; Parveen Sajiya; Rawat Kundan Singh; Goenka Shradha | ||
| IPC Classification: | A61P 31/10, C07K 14/47, C12Q 1/68, C12Q 1/6844 | ||
| Abstract: | The present invention relates to substituted 3-methylbenzo[d]thiazol-3-ium compounds, their nucleic acid conjugates, complexes, salts which are potentially useful for cell imaging applications, diagnostics, fluorescent tags, pharmaceuticals and other useful molecular biology applications, and a process of preparation thereof. More particularly, the present invention relates to 3-methyl-2-((2-substituted-1-phenylquinolin-4(1H)ylidene)methyl)-benzo[d]thiazol-3-ium compounds, processes for preparing said compounds and their uses for detection of nucleic acids in fluorescence-based imaging and analysis. Specifically, the present invention pertains to a new, dual-function DNA gel stain Compound 1, which serves as an effective nucleic acid stain, demonstrating high sensitivity and affinity towards various nucleic acids, including genomic DNA, PCR products, plasmids, and RNA. Additionally, Compound 1 enhances Real-Time Polymerase Chain Reaction processes by providing improved Relative Fluorescence Units values and enabling the amplification of larger targets. Uniquely, Compound 1 does not necessitate any special or hazardous waste disposal procedures, making it a safer and environmentally sustainable choice for laboratories. |
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: director[at]cdri[dot]res[dot]in
:91-522-2772450
:https://www.cdri.res.in