New Invention Profile
| Publication No: | IN202211040311 [India] | Application No: | 202211040311 |
| Title: | Substituted 3-methylbenzo[d]thiazol-3-ium compounds and use thereof | ||
| Publication Date: | 19-01-2024 | File Date: | 12-07-2022 |
| Inventor(s): | Goel, Atul; Parveen, Sajiya; Rawat, Kundan Singh; Goenka, Shradha | ||
| IPC Classification: | G01, C12 | ||
| Abstract: | The present invention relates to substituted 3-methylbenzo[d]thiazol-3-ium compounds of the general formula I and their nucleic acid conjugates, complexes, salts which are potentially useful for cell imaging applications, diagnostics, fluorescent tags, pharmaceuticals and other useful molecular biology applications, and a process of preparing said new compounds. More particularly, the present invention relates to 3-methyl-2-((2-substituted-1-phenylquinolin-4(1H)ylidene)methyl)-benzo[d]thiazol-3-ium compounds, processes for preparing the said compounds and their uses for detection of nucleic acids in fluorescence-based imaging and/or analysis. Specifically, the present invention pertains to a new, dual-function DNA gel stain Compound 1, which serves as an effective nucleic acid stain, demonstrating high sensitivity and affinity towards a range of nucleic acids, including genomic DNA, PCR products, plasmids, and RNA. Additionally, Compound 1 enhances Real-Time Polymerase Chain Reaction (RT-PCR) processes by providing improved Relative Fluorescence Units (RFU) values and enabling the amplification of larger targets. Uniquely, Compound 1 does not necessitate any special or hazardous waste disposal procedures, making it a safer and more environmentally sustainable choice for laboratories. | ||
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Industrial Applications
Chemistry, Chemical Processes Polymers [Chemistry, Chemical Processes]
Synhtesis Procesess [Drugs and Pharmaceuticals]