New Invention Profile
| Publication No: | EP4347595 [Europe] | Application No: | EP22815523 |
| Title: | Substituted tricyclic heterocyclic compounds as metallo-beta-lactamase inhibitors | ||
| Publication Date: | 25-06-2025 | File Date: | 02-06-2022 |
| Inventor(s): | Chaudhari Vinod Dinkar; Dhiman Pulkit; Nandanwar Hemraj Santuji; Pathania Vikas; Thakur Krishan Gopal; Das Satyajeet | ||
| IPC Classification: | C07D471/14, A61K31/4045, A61P31/04, C07D209/60 | ||
| Abstract: | The invention relates to substituted tricyclic heterocyclic compounds of formula (I), pharmaceutically acceptable salts thereof and pharmaceutical compositions wherein, R1, R2, R3, R4, R5, R6, R7, R8, R9, 5 R10, R11, X1, X2, X3, X4, X5 and 'n' defined herein. The present invention also relates to compositions which comprise a metallo-β-lactamase (MBL) inhibitor compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, optionally in combination with a beta-lactam antibiotic and/or a beta-lactamase inhibitor. The invention further relates to methods for treating a bacterial infection comprising administering to a patient a 10 therapeutically effective amount of a compound of the invention, in combination with a therapeutically effective amount of one or more β-lactam antibiotics and optionally in combination with one or more beta-lactamase inhibitor compounds. The compounds of the invention are useful in the methods described herein for reducing or overcoming antibiotic resistance. 15 Formula I 20 25 |
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CSIR-Institute of Microbial Technology[CSIR-IMTECH]
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: director[at]imtech[dot]res[dot]in
:91-172-2690550
:https://www.imtech.res.in
Industrial Applications
Diagnostics [Medical Devices and Diagnostics]
NCE [Drugs and Pharmaceuticals]
Nutraceuticals [Drugs and Pharmaceuticals]