New Invention Profile
| Publication No: | US20240279176 [USA] | Application No: | US18565742 |
| Title: | Substituted tricyclic heterocyclic compounds as metallo-beta-lactamase inhibitors | ||
| Publication Date: | 22-08-2024 | File Date: | 30-11-2023 |
| Inventor(s): | Chaudhari, Vinod Dinkar; Dhiman, Pulkit; Nandanwar, Hemraj Santuji; Pathania, Vikas; Thakur, Krishan Gopal; Das, Satyajeet | ||
| IPC Classification: | C07D 020960, A61K 0031403, A61K 0031407, A61K 00314439, A61K 0031506, A61P 003104, C07C 0029143, C07C 004542, C07C 022712, C07D 040104, C07D 040304 | ||
| Abstract: | The invention relates to substituted tricyclic heterocyclic compounds of formula (I), pharmaceutically acceptable salts thereof and pharmaceutical compositions wherein, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, X1, X2, X3, X4, X5 and 'n' defined herein. The present invention also relates to compositions which comprise a metallo-β-lactamase (MBL) inhibitor compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, optionally in combination with a beta-lactam antibiotic and/or a beta-lactamase inhibitor. The invention further relates to methods for treating a bacterial infection comprising administering to a patient a therapeutically effective amount of a compound of the invention, in combination with a therapeutically effective amount of one or more β-lactam antibiotics and optionally in combination with one or more beta-lactamase inhibitor compounds. The compounds of the invention are useful in the methods described herein for reducing or overcoming antibiotic resistance. |
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Industrial Applications
Chemistry, Chemical Processes Polymers [Chemistry, Chemical Processes]
Speciality Chemicals [Chemistry, Chemical Processes]